Total royalty revenues were $0.9 million in the first quarter of 2013, compared to $0.7 million in the first quarter of 2012, reflecting increased royalty revenues from Actavis on CRINONE items. Columbia expects to continue to get from Actavis royalty revenues of 10 percent of U.S. Net sales of certain progesterone items, including CRINONE and the next-generation CRINONE product, for the near future. As a result, total net revenues for the first quarter of 2013 were $6.3 million, compared to $3.8 million for the initial quarter of 2012, an increase of 65 percent.But unlike a lot of its neighbors, this one-celled yeast can also cause disease, ranging from thrush and vaginal yeast infections to systemic bloodstream infections that cause organ failure and death and usually occur in people who have immune defects linked to HIV/AIDS, organ transplantation or chemotherapy. C. Albicans is responsible for 400,000 deaths annually. Scientists have long thought that C. Albicans reproduce without mating. Organisms that produce asexually or parasexually are diploid, which means they possess two sets of chromosomes and thus can reproduce with out a mate. Organisms that reproduce are haploid sexually, which means they have one group of chromosomes and want a mate to supply a second set.