Clonal evolution explains unpredictable leukemia disease course By Lynda Williams.

Clonal evolution explains unpredictable leukemia disease course By Lynda Williams, Senior medwireNews Reporter Researchers have revealed the complicated clonal evolution of chronic lymphocytic leukemia , giving insight into the variation in disease training course and its own response to treatment. Gad Getz and group used whole-exome sequencing to examine subclonal mutations in 149 CLL patients. Analysis revealed how CLL develops over time, following the accumulation of cell events resulting in a clonal mutation . The founding CLL clonal mutation in one cell is driven by mutations such as , MYD88, and trisomy 12 that recur across patients; these have been suggested to operate a vehicle CLL and B cell malignancies previously.

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