Clonal evolution explains unpredictable leukemia disease course By Lynda Williams, Senior medwireNews Reporter Researchers have revealed the complicated clonal evolution of chronic lymphocytic leukemia , giving insight into the variation in disease training course and its own response to treatment. Gad Getz and group used whole-exome sequencing to examine subclonal mutations in 149 CLL patients. Analysis revealed how CLL develops over time, following the accumulation of cell events resulting in a clonal mutation www.lady-era.net/treating-female-infertility-with-sildenafil.html . The founding CLL clonal mutation in one cell is driven by mutations such as , MYD88, and trisomy 12 that recur across patients; these have been suggested to operate a vehicle CLL and B cell malignancies previously.
Samuel Wong and colleagues followed up 1726 men, aged typically 72.1 years, over 2 years. They discovered that the 686 men with average or severe LUTS symptoms at baseline according to the International Prostatic Symptoms Rating were 2.5-fold more likely to have clinically relevant depressive symptoms at calendar year 2 than men with no or mild symptoms , after adjusting for confounders. Related StoriesStudy shows link between exercise and depression in patients at risk for heart diseaseEstradiol fluctuation may enhance emotional sensitivity to psychosocial tension during menopausal transitionStudy suggests a neural pathway through which early life stress may donate to depressionOther factors connected with major depression on the Geriatric Melancholy Scale at follow-up included unhappiness at baseline, having diabetes, and experiencing several stressful life event during the study.